POSTER: Computational Analysis of Multiplexed Immunohistochemistry for Understanding Immune Profiles in Clinical Biopsy Samples
Abstract Using immunohistochemistry (IHC) to examine immune infiltrates in tissue biopsy samples to support exploratory investigations for immuno-oncology drug development is critical for understanding the
POSTER: Analysis of Multiplexed Immunotherapy Targets and Secreted Ligands Using Computational Tumor Microenvironment Profiling
Abstract As the number and diversity of cellular and signaling pathway therapeutic targets in immuno-oncology increases, more therapy combinations are aimed at multiple cell types
CASE STUDY: Multiplex Assays with Coregistration Enables Multiple Biomarker Analyses Across Tissue Sections
Summit Therapeutics, a life sciences company developing a therapy for Duchenne muscular dystrophy (DMD), was faced with a drug development challenge. They needed to accurately
WHITE PAPER: Getting the Whole Picture for Immuno-Oncology Therapies
Key Concepts: Immuno-oncology (IO) therapies have changed the way we think about patient selection for precision medicine. The complexity of tumor/immune interactions creates an opportunity
POSTER: Analytical Validation of Ki67/CD8 Duplex IHC Assay Using Computational Tissue Analysis (cTA®)
Abstract: Chromogenic multiplex immunohistochemistry (IHC) assays enable investigation of the spatial relationships between tumor cells and immune cells, which are thought to be important for
POSTER: Evaluating Benefits of PD-L1 Image Analysis for the Clinical Setting
Abstract: Tissue-based investigations can prove to be challenging due to complex tissue architecture, heterogeneous biomarker expression, visual and cognitive “traps” that affect interpretive precision, and
