POSTER: Analysis of Multiplexed Immunotherapy Targets and Secreted Ligands Using Computational Tumor Microenvironment Profiling
Abstract As the number and diversity of cellular and signaling pathway therapeutic targets in immuno-oncology increases, more therapy combinations are aimed at multiple cell types
CASE STUDY: Multiplex Assays with Coregistration Enables Multiple Biomarker Analyses Across Tissue Sections
Summit Therapeutics, a life sciences company developing a therapy for Duchenne muscular dystrophy (DMD), was faced with a drug development challenge. They needed to accurately
WHITE PAPER: Getting the Whole Picture for Immuno-Oncology Therapies
Key Concepts: Immuno-oncology (IO) therapies have changed the way we think about patient selection for precision medicine. The complexity of tumor/immune interactions creates an opportunity
POSTER: Analytical Validation of Ki67/CD8 Duplex IHC Assay Using Computational Tissue Analysis (cTA®)
Abstract: Chromogenic multiplex immunohistochemistry (IHC) assays enable investigation of the spatial relationships between tumor cells and immune cells, which are thought to be important for
POSTER: Evaluating Benefits of PD-L1 Image Analysis for the Clinical Setting
Abstract: Tissue-based investigations can prove to be challenging due to complex tissue architecture, heterogeneous biomarker expression, visual and cognitive “traps” that affect interpretive precision, and
POSTER: Computational Tissue Analysis-Based Quantification of Tumor-Infiltrating Leukocytes Using Morphometrics in Immunohistochemistry-Stained NSCLC Samples
Abstract Background: Quantification of tumor-infiltrating lymphocytes (TILs) is predictive of patient response to immunotherapy regimens. Because of the role of anti-PD-L1 and anti-PD-1 treatments in
