Abstract: The anti-PD-L1 antibody (22C3) is used as a companion diagnostic for successful checkpoint inhibitor therapy in head and neck squamous cell carcinoma. The positive predictive value of this assay, however, is less than ideal as a high PD-L1 score does not...
Publications / Posters
Macrophage Biomarkers CD68 and CD163 Correlate with CRC Patient Survival (Poster No. 2530 at #AACR2022)
Key Takeaways CRC patient survival correlates with the presence or absence of macrophage biomarkers CD68, CD163, and a lack of PD-L1. Lower levels of ‘M1/anti-tumor’ CD68+ or CD68+CD163– cells correlate with increased survival. Higher levels of ‘M2/pro-tumor’ CD163+...
Macrophage Biomarkers CD68 and CD163 Correlate with NSCLC Patient Survival (Poster No. 1720 at #AACR2022)
Key Takeaways Image analysis is able to use immune biomarkers to correlate immune cell presence and localization with patient survival in NSCLC. Patient survival correlates with the presence or absence of CD68 and CD163 macrophage markers, but these markers do not...
Virtual Centralized Pathology = More Accurate Patient Data (Poster No. 10018 at Digital Pathology Association’s Pathology Visions 2021 #pathvisions21)
Background Historically, immunohistochemistry (IHC) assays have been designed for simplicity of manual pathology, however, this is not always ideal to acquire the appropriate data for patient selection and outcomes. Due to various challenges within the current...
Original Research Article (Pfizer): First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7 (PTK7), in Advanced Solid Tumors
In the downloadable original research article sponsored by Pfizer, the digital tissue analysis was performed using the Flagship Biosciences proprietary Image Analysis platform. The article was published in the Journal: Clinical Cancer Research online first on June 3,...
Original Research Article: Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors
In partnership with Leap Therapeutics (Nasdaq: LPTX), a biotechnology company focused on developing targeted and immuno-oncology therapeutics, Flagship Biosciences published this downloadable original research article. It was first published on Monday, May 10...
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Recent Posts
NEWS
Scientist Spotlight: David Henderson, PhD
Dr. Henderson is Vice President of Computational & Imaging Sciences at Flagship. With a passion for innovative technology and solving problems for clients, Dr. Henderson not only inspires his team but also pushes the boundaries of what’s possible in our industry....
Flagship Biosciences and Offspring Biosciences Partner to Provide Complete Global Assay Development Services from Target Identification to Companion Diagnostics
Unlocking the combined value of Offspring’s innovative pre-clinical solutions with Flagship’s clinical trial data-driven assay solutions. Broomfield, CO, USA and Södertälje, Sweden – January 23, 2024 – Flagship Biosciences, a leader in spatial biology and biomarker...
Flagship Biosciences Is Honored with a Best Practices Award
We are honored to announce that Flagship Biosciences has earned a Frost & Sullivan 2023 North American Customer Value Leadership Award in the AI-enabled digital pathology solutions market. Following from detailed evaluation of best practices criteria, the award...
EVENTS
2nd Annual Spatial Biology for Drug Development Summit
Meet us at the 2nd annual Spatial Biology for Drug Development Summit. We’re excited to be a Program Partner for the Spatial Biology for Drug Development Summit, returning to Boston for a 2nd year, October 22-24. This year, we’ll dive into the latest in spatial omics...
14th Annual World Clinical Biomarkers and Companion Diagnostics Summit
Meet with us in Boston for World CB & CDx.We’re thrilled to be a Spotlight Partner for the 14th World Clinical Biomarkers and Companion Diagnostics Summit. Join us there to exchange insights with biotech and pharma leaders, researchers, and scientists and to discuss...
Spatial Biology East Coast US 2024
Meet with us at booth #25. As a Gold Sponsor for the third annual Spatial Biology East Coast Congress in Boston, we hope you’ll join our experts and over 350 other industry leaders to discuss the transforming field of spatial biology. Examine how spatial biology can...