Methodology for Designing and Validating Computational Pathology Scores for Immune Cell Clustering in Tumor Biopsy Samples

Key takeaways

  • Understanding the frequency and nature of immune cell clustering is useful in determining patient responses to immunomodulating therapies
  • Flagship’s unique spatial biology services generated a validated computational pathology score that characterized the clustering of CD8+ stained cells from NSCLC biopsy samples
  • Samples with similar biomarker expression levels had different immune cell clustering profiles
  • Ultimately, the computational pathology scores provide more detailed information regarding the immune phenotype

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