Quantitative dermatopathology is just scratching the surface with digital pathology
We have a number of multi-modal whole slide scanning techniques that we call bridge scanning, where a number of fluorescent and brightfield scans are overlaid, either from a single slide or from multiple consecutive sections. In this example, we are using FACTS with other consecutive sections to identify biocompatible responses to implanted biopolymers. We can [...]
Quantification of proliferating nuclei with multiplexed IHC in between melanoma and melanocytic nevi.
This example came from healthy porcine aorta that was stained with Hematoxylin and Eosin (H&E). Using an area-based algorithm, we can quantitatively evaluate the sample for elastin percentage. Elastin is a critical component of the microstructure within large arteries such as the aorta. This type of quantitative analysis can be performed on various types of [...]
White fat measurement is shown below with a Flagship algorithm that first segments and then individually identifies each fat vacuole. Statistics of area and perimeter per vacuole are counted, and histograms can be output as required. Some results are shown below. In areas where vacuoles are either not easily seen by eye, or where they [...]
